| Course Unit Code | Course Unit Title | Type of Course Unit | Year of Study | Semester | Number of ECTS Credits | | FBİ731-14 | EPIGENETICS | Compulsory | 1 | 1 | 6 |
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| Level of Course Unit |
| Third Cycle |
| Objectives of the Course |
| To learn independent processes from the primary DNA sequence that lead to heritable changes in phenotype, relationships of epigenetic processes with other cellular processes and connection of other human diseases with these processes. In addition, to follow therapeutic approaches for these diseases and current technological developments. |
| Name of Lecturer(s) |
| Doç. Dr. Zülal ATLI ŞEKEROĞLU - Doç. Dr. Vedat ŞEKEROĞLU |
| Learning Outcomes |
| 1 | Epigenetik süreçleri ve kalıtım şeklini öğrenir | | 2 | Epigenetik mekanizmaları tanır ve ilgili yolaklar hakkında bilgi edinir. | | 3 | İlişkili hastalıkları ve geliştirilen tedavi sistemlerini bilir | | 4 | Learn epigenetic processes and the pattern of inheritance | | 5 | Obtain knowlage on related pathways and epigenetics mechanisms | | 6 | Know associated deseases and developed treatment system |
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| Mode of Delivery |
| Formal Education |
| Prerequisites and co-requisities |
| None |
| Recommended Optional Programme Components |
| None |
| Course Contents |
| The historical development of epigenetics, epigenetic processes and their functions, epigenetic model organisms, related technological developments, inheritance mechanisms of epigenetics , DNA Methylation, Histone modifications, chromatin remodelling, non-coding RNAs, prion proteins, Polycomb protein group, genomic imprinting, gene silencing, diseases associated with epigenetic and their treatments. |
| Weekly Detailed Course Contents |
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| 1 | Definition of Epigenetics, its historical development and technological developments on epigenetics | 3 | 0 | | 2 | Summarizing the issues associated with epigenetics (model organism, epidemiology and evolutionary epigenetic) | 3 | 0 | | 3 | In mammals, DNA methylation, its importance in the control of gene expression and demethylation | 3 | 0 | | 4 | Histone modifications and chromatin remodelling | 3 | 0 | | 5 | Histone modifications and chromatin remodelling | 3 | 0 | | 6 | X-inactivation and dosage compensation | 3 | 0 | | 7 | Midterm exam | 2 | 1 | | 8 | The role of non-coding RNAs in the regulation of gene expression | 3 | 0 | | 9 | Gene silencing and Polycomb proteins | 3 | 0 | | 10 | Transposons, the position effect and heterochromatin structure | 3 | 0 | | 11 | Gene imprinting, epigenetic inheritance and Prions | 3 | 0 | | 12 | The importance of epigenetics on stem cell behavior and cell differentiation | 3 | 0 | | 13 | Aging epigenetics | 3 | 0 | | 14 | Cancer epigenetics | 3 | 0 | | 15 | Human diseases associated with epigenetics and cancer, treatment approaches for them | 3 | 0 | | 16 | Final exam | 2 | 1 |
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| Recommended or Required Reading |
| Epigenetics and Chromatin. P. Jeanteur, Progress in Molecular and Subcellular Biology, Springer. 2005.
Epigenetics. C.D. Allis, T. Jenuwein, D. Reinberg, Cold Spring Harbor Laboratory Press. 2006
Handbook of Epigenetics, The new molecular and medical genetics. T. Tollefsbol, Academic Press Elsevier, 2011. |
| Planned Learning Activities and Teaching Methods |
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| Assessment Methods and Criteria | |
| SUM | 0 | |
| SUM | 0 | | Yarıyıl (Yıl) İçi Etkinlikleri | 40 | | Yarıyıl (Yıl) Sonu Etkinlikleri | 60 | | SUM | 100 |
| | Language of Instruction | | | Work Placement(s) | | None |
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| Workload Calculation |
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| Midterm Examination | 1 | 2 | 2 |
| Final Examination | 1 | 2 | 2 |
| Quiz | 10 | 1 | 10 |
| Attending Lectures | 10 | 3 | 30 |
| Laboratory | 10 | 1 | 10 |
| Problem Solving | 10 | 1 | 10 |
| Discussion | 10 | 2 | 20 |
| Question-Answer | 10 | 1 | 10 |
| Brain Storming | 10 | 1 | 10 |
| Report Preparation | 5 | 2 | 10 |
| Report Presentation | 5 | 1 | 5 |
| Project Preparation | 5 | 2 | 10 |
| Project Presentation | 5 | 1 | 5 |
| Criticising Paper | 10 | 1 | 10 |
| Self Study | 5 | 1 | 5 |
| Individual Study for Homework Problems | 5 | 1 | 5 |
| Individual Study for Mid term Examination | 3 | 2 | 6 |
| Individual Study for Final Examination | 5 | 2 | 10 |
| Reading | 10 | 1 | 10 |
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| Contribution of Learning Outcomes to Programme Outcomes |
| LO1 | | 2 | | 3 | | 3 | 3 | 5 | 1 | 1 | | | LO2 | | | | | 4 | 5 | | | 3 | 3 | | | LO3 | 5 | 4 | 4 | 4 | | | 4 | | | 5 | 2 | | LO4 | | | | | | | | | | | | | LO5 | | | | | | | | | | | | | LO6 | | | | | | | | | | | |
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| * Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High |
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