| Course Unit Code | Course Unit Title | Type of Course Unit | Year of Study | Semester | Number of ECTS Credits | | TBK604 | BASIC ENZYMOLOGY | Compulsory | 1 | 2 | 6 |
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| Level of Course Unit |
| Second Cycle |
| Objectives of the Course |
| The aim of this lecture is to teach definition, structure and function of enzymes, factors that effects enzymatic reaction, study of single and multisubstrate enzymatic reactions, allosteric enzymes, enzyme inhibition, discussion of enzymes in normal and pathological conditions. |
| Name of Lecturer(s) |
| Doç. Dr. Ahmet Bayrak |
| Learning Outcomes |
| 1 | Describes the basics of an enzyme catalyzed reaction. | | 2 | Calculates the kinetic constants | | 3 | Describes the behavior of the enzyme rate. | | 4 | valuates experimental findings and could be to develop an appropriate model for the behavior of the enzyme | | 5 | Uses its knowledge at scientific researchs |
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| Mode of Delivery |
| Formal Education |
| Prerequisites and co-requisities |
| None |
| Recommended Optional Programme Components |
| None |
| Course Contents |
| In this course, students learn the structure and function of enzyme ; sthe kinetic mechanism and kinetic behavioral models of an enzymatic reaction, calculates the kinetic constants of an enzyme catalyzed reaction |
| Weekly Detailed Course Contents |
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| 1 | Structures and properties of enzymes | 2 | 2 | | 2 | Enzyme Classification | 4 | | | 3 | Determanition of Enzyme Activity | | 4 | | 4 | Factors affecting the rate of enzymatic reaction-I: enzyme, substrate concentration, temperature and pH of the experimental media | 2 | 2 | | 5 | Rapid equilibrium steady-state approaches | 2 | 2 | | 6 | Michaelis-Menten and Lineweaver-Burk plots | 2 | 2 | | 7 | Factors affecting the rate of enzymatic reaction-II: enzyme, substrate concentration, temperature and pH of the media: reversible, irreversible inhibitors, activators | 2 | 2 | | 8 | Exam | 1 | | | 9 | Inhibition Kinetics I, Competitive inhibition | 2 | 2 | | 10 | Inhibition Kinetics I, Noncompetitive inhibition | 2 | 2 | | 11 | Inhibition Kinetics I, Uncompetitive inhibition | 2 | 2 | | 12 | İrreversible inhibitions | 2 | 2 | | 13 | Allosteric ezymes | 2 | 2 | | 14 | Allosteric ezymes and metabolic regülation | 2 | 2 | | 15 | Enzymes in clinical diagnosis | 2 | 2 | | 16 | Final exam | 2 | 2 |
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| Recommended or Required Reading |
| Champe PC, Harvey RA, Ferrier DR. Lippincott’s Biyokimya. (Ulukaya E), 2007, Nobel Tıp Kitapevleri, Ankara
Nelson DL, Cox MM. Lehninger Biyokimyanın İlkeleri. (Kılıç N), 2004, Palme Yayıncılık, Ankara
Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper Biyokimya (Dikmen N, Özgünen T), 2004, Nobel Tıp Kitapevleri, Ankara |
| Planned Learning Activities and Teaching Methods |
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| Assessment Methods and Criteria | |
| SUM | 0 | |
| SUM | 0 | | Yarıyıl (Yıl) İçi Etkinlikleri | 40 | | Yarıyıl (Yıl) Sonu Etkinlikleri | 60 | | SUM | 100 |
| | Language of Instruction | | Turkish | | Work Placement(s) | | None |
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| Workload Calculation |
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| Midterm Examination | 1 | 1 | 1 |
| Final Examination | 1 | 1 | 1 |
| Attending Lectures | 28 | 2 | 56 |
| Laboratory | 7 | 2 | 14 |
| Problem Solving | 20 | 1 | 20 |
| Team/Group Work | 5 | 1 | 5 |
| Experiment | 7 | 2 | 14 |
| Seminar | 1 | 15 | 15 |
| Self Study | 14 | 1 | 14 |
| Individual Study for Homework Problems | 5 | 2 | 10 |
| Individual Study for Mid term Examination | 1 | 15 | 15 |
| Individual Study for Final Examination | 1 | 20 | 20 |
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| Contribution of Learning Outcomes to Programme Outcomes |
| LO1 | 5 | 5 | 5 | 5 | 2 | 1 | 1 | 2 | 5 | 5 | 5 | 3 | 5 | | LO2 | | 2 | 2 | 2 | 2 | 1 | | 1 | | 1 | 3 | | 5 | | LO3 | 1 | 4 | 5 | 5 | 3 | 2 | 1 | 2 | 5 | 3 | 5 | 1 | 5 | | LO4 | 3 | 5 | 4 | 5 | 4 | 3 | 1 | 2 | 5 | 3 | 5 | 5 | 5 | | LO5 | 1 | 5 | 3 | 5 | 5 | 5 | 5 | 2 | 5 | 5 | 5 | 4 | 5 |
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| * Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High |
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