| Course Unit Code | Course Unit Title | Type of Course Unit | Year of Study | Semester | Number of ECTS Credits | | FBK654-13 | CARBONYL ALPHA-SUBSTITUTION AND CARBONYL CONDENSATION REACTIONS | Compulsory | 1 | 1 | 6 |
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| Level of Course Unit |
| Second Cycle |
| Objectives of the Course |
| Keto-Enol tautomerism
Reactivity of enols, alpha substitution reactions
Reactivity of enolate ions and its alkylation
Carbonyl Condensations, The Aldol Reaction
Carbonyl Condensations versus alpha substitution reactions
Synthesis of enones, using Aldol reactions in synthesis
Mixed Aldol reactions
Itramolecular Aldol reactions
The Claisen Condensation
Itramolecular Claisen condensations, Dieckmann cyclization
Conjugate Carbonyl Additions
Carbonyl Condensations with enamines, the Stork reaction
The Robinson Annulation reactions
The other condensation reactions
Some Biological Carbonyl Condensation Reactions
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| Name of Lecturer(s) |
| Prof. Dr. Latif KELEBEKLİ |
| Learning Outcomes |
| 1 | Keto-enol tautomers, reactivity of Enol provides information about alpha substitution reactions. | | 2 | It has information about the reactivity of the enolate ions and the alkylation of carbonyl condensations | | 3 | Aldol reaction learns carbonyl condensations against alpha substitution. | | 4 | They are informed about the synthesis of enones and the use of aldol reactions in synthesis. |
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| Mode of Delivery |
| Formal Education |
| Prerequisites and co-requisities |
| None |
| Recommended Optional Programme Components |
| None |
| Course Contents |
| Keto-Enol tautomerism
Reactivity of enols, alpha substitution reactions
Reactivity of enolate ions and its alkylation
Carbonyl Condensations, The Aldol Reaction
Carbonyl Condensations versus alpha substitution reactions
Synthesis of enones, using Aldol reactions in synthesis
Mixed Aldol reactions
Itramolecular Aldol reactions
The Claisen Condensation
Itramolecular Claisen condensations, Dieckmann cyclization
Conjugate Carbonyl Additions
Carbonyl Condensations with enamines, the Stork reaction
The Robinson Annulation reactions
The other condensation reactions
Some Biological Carbonyl Condensation Reactions
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| Weekly Detailed Course Contents |
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| 1 | Keto-Enol tautomerism
| | | | 2 | Reactivity of enols, alpha substitution reactions
| | | | 3 | Reactivity of enolate ions and its alkylation
| | | | 4 | Carbonyl Condensations, The Aldol Reaction
| | | | 5 | Carbonyl Condensations versus alpha substitution reactions
| | | | 6 | Synthesis of enones, using Aldol reactions in synthesis
| | | | 7 | Mixed Aldol reactions
| | | | 8 | MIDTERM EXAM | | | | 9 | Itramolecular Aldol reactions
| | | | 10 | The Claisen Condensation
| | | | 11 | Itramolecular Claisen condensations, Dieckmann cyclization
| | | | 12 | Conjugate Carbonyl Additions
| | | | 13 | Carbonyl Condensations with enamines, the Stork reaction
| | | | 14 | The Robinson Annulation reactions
| | | | 15 | Some Biological Carbonyl Condensation Reactions | | | | 16 | FINAL EXAM | | |
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| Recommended or Required Reading |
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| Planned Learning Activities and Teaching Methods |
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| Assessment Methods and Criteria | |
| SUM | 0 | |
| SUM | 0 | | Yarıyıl (Yıl) İçi Etkinlikleri | 40 | | Yarıyıl (Yıl) Sonu Etkinlikleri | 60 | | SUM | 100 |
| | Language of Instruction | | Turkish | | Work Placement(s) | | None |
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| Workload Calculation |
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| Midterm Examination | 1 | 2 | 2 |
| Final Examination | 1 | 2 | 2 |
| Attending Lectures | 14 | 3 | 42 |
| Problem Solving | 8 | 2 | 16 |
| Discussion | 8 | 2 | 16 |
| Question-Answer | 8 | 2 | 16 |
| Criticising Paper | 8 | 2 | 16 |
| Self Study | 6 | 2 | 12 |
| Individual Study for Homework Problems | 8 | 2 | 16 |
| Individual Study for Mid term Examination | 10 | 2 | 20 |
| Individual Study for Final Examination | 14 | 2 | 28 |
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| Contribution of Learning Outcomes to Programme Outcomes |
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| * Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High |
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